Related Experiment Video
Updated: May 31, 2026
12:22
Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
Published on: August 4, 2018
Computational aberration correction enables full-thickness retinal imaging with adaptive optics optical coherence
Dawid Borycki1,2, Zhuolin Liu3, Daniel X Hammer3
1International Centre for Translational Eye Research, Skierniewicka 10A, 01-230 Warsaw, Poland.
Biocybernetics and Biomedical Engineering
|May 29, 2026
Summary
Computational defocus correction simplifies adaptive optics optical coherence tomography (AO-OCT) imaging. This method extends the depth of focus, improving cellular visualization across the entire retina without multiple scans.
Area of Science:
- Ophthalmology
- Biomedical Optics
- Medical Imaging
Background:
- Biomedical optical imaging provides noninvasive evaluation of ocular and systemic diseases.
- Adaptive optics optical coherence tomography (AO-OCT) offers in vivo, cellular-level retinal imaging.
- AO-OCT's limited depth of focus (DOF) necessitates multi-volume acquisition for full retinal imaging.
Purpose of the Study:
- To simplify AO-OCT imaging by computationally extending the depth of focus.
- To demonstrate the efficacy of computational defocus correction within a computational aberration correction (CAC) framework.
- To reduce imaging complexity and session duration for improved clinical viability.
Main Methods:
- Applied computational aberration correction (CAC) to AO-OCT volumes.
- Acquired AO-OCT volumes with the system focus at a single mid-retinal plane.
- Post-processed data to correct depth-dependent defocus and restore cellular sharpness.
Main Results:
- Computational defocus correction effectively extended the DOF, restoring cellular sharpness throughout the entire retina.
- CAC enhanced en face AO-OCT images, even in peripheral retinal regions.
- Improved rendering of cellular structures was observed in eyes with retinal pathology.
Conclusions:
- Computational defocus correction integrated with AO-OCT simplifies imaging and extends DOF without sequential refocusing.
- This hybrid AO-OCT + CAC approach reduces imaging complexity and session duration.
- The method shows translational potential for clinical applications, including imaging retinal pathology.
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