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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

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Published on: February 12, 2017

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[News treatments and survival in lung cancer]

Mehdi Lamkhioued1, Thomas Pierret1

  • 1Service de pneumologie, hôpital Louis-Pradel, Hospices civils de Lyon, Lyon, France.

La Revue Du Praticien
|February 23, 2023
PubMed

Insights

Novel therapies targeting oncogenes like EGFR and ALK have transformed non-small cell lung cancer (NSCLC) treatment. These advancements, including immune-based therapies, have significantly improved patient survival and quality of life.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunotherapy

Context:

  • The treatment landscape for non-squamous cell lung cancer (NSCLC) has undergone significant transformation since the early 2000s.
  • Identification of targetable oncogenes, including epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), has been pivotal.

Purpose:

  • To review the evolution of lung cancer treatment paradigms.
  • To highlight the impact of targeted therapies and immunotherapy on NSCLC outcomes.

Summary:

  • The advent of targeted therapies (e.g., EGFR, ALK inhibitors) and immune-based therapies has revolutionized NSCLC management.
  • Systemic treatments are now integrated across all stages of lung cancer, complementing traditional approaches like surgery and radiotherapy.
  • These therapeutic advances have led to a decline in lung cancer incidence and mortality.

Impact:

  • Improved survival rates and enhanced quality of life for lung cancer patients.
  • Establishment of immune-based therapies as a cornerstone in NSCLC treatment.
  • Shift in systemic drug application from advanced stages to broader integration in multimodal therapy.

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