[Perspectives in the management of childhood obesity]

PERSPECTIVES IN THE MANAGEMENT OF CHILDHOOD OBESITY. Progress in the understanding of the mechanisms of childhood obesity opens up therapeutic perspectives for its management and possible prevention of massive obesity. Considering as a disease of the weight regulation centres with high genetic component, classical treatments integrating dietetics and physical activity have shown their limits and their long-term inefficiency in children with high-risk of developing severe obesity. The development of new molecules targeting genetic forms of obesity due to interruption of the leptin/melanocortin pathway and of the GLP-1 agonists in common obesity are recent major prospects. Finally, modulation of the microbiota by dietary and/or pre-probiotic factors could also be an attractive prospect needed to be confirmed. These recent advances will help to the development of precision medicine in childhood obesity avoiding the inevitable worsening of weight gain, particularly in the most predisposed children, and the development of massive obesity in adulthood.