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Related Experiment Video

Updated: Aug 9, 2025

A Melanoma Patient-Derived Xenograft Model

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

Current Controversies in Melanoma Treatment.

Claire Temple-Oberle¹, Christine Nicholas¹, Priscila Rojas-Garcia¹

¹From the Clinical Department of Oncology, Calgary Zone, Section of Surgical Oncology, Tom Baker Cancer Centre.

Plastic and Reconstructive Surgery

|February 23, 2023

Summary

Advances in melanoma management offer personalized risk assessment for sentinel node biopsy and refined surgical techniques. This includes digit-sparing options for subungual melanoma and lymphatic reconstruction to reduce lymphedema risk after lymphadenectomy.

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

Plastic surgery
Dermatology
Oncology

Background:

Melanoma treatment is rapidly advancing, requiring plastic surgeons to stay updated on new techniques and evidence-based practices.
Current management involves considerations for surgical margins, reconstruction, and staging.
Novel approaches are emerging for various stages and presentations of melanoma.

Purpose of the Study:

To provide an overview of current advances in melanoma management.
To discuss evolving surgical techniques and reconstructive options.
To highlight personalized risk assessment and novel therapeutic modalities.

Main Methods:

Review of current literature and surgical techniques in melanoma management.
Discussion of reconstructive options, including the keystone flap.
Explanation of predictive nomograms for sentinel node biopsy risk stratification.
Description of techniques for lymphadenectomy and lymphatic reconstruction.
Overview of management strategies for in-transit melanoma.

Main Results:

Appropriate margins for in situ and invasive melanoma are based on current trial data.
The keystone flap is a versatile option for wide excision defects.
Digit-sparing alternatives exist for subungual melanoma.
Personalized risk estimates for sentinel node positivity are now achievable.
Minimally invasive options are available for in-transit melanoma recurrence.

Conclusions:

Plastic surgeons must integrate evolving evidence into melanoma treatment planning.
Advanced surgical techniques, including the keystone flap and digit-sparing approaches, enhance outcomes.
Personalized risk assessment and novel reconstructive techniques, such as lymphatic reconstruction, improve patient care and reduce morbidity.