Related Experiment Video
Updated: Aug 9, 2025
A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Pulmonary Functions and Oxidative Stress Biomarkers Among Silica-Exposed Foundry Workers
Asmaa Mohamed Hussein1, Dalia Ismail Attia, Bahaa El-Din Mostafa Zayed
1From the Department of Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt (A.M.H., D.I.A., G.H.E.-D.E.-S.); Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt (B.E.-D.M.Z.); and Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt (L.A.R.).
Objective:
To investigate the changes of the ventilatory function tests and the oxidative stress biomarkers among silica-exposed foundry workers.
Methods:
The exposed group included 70 workers in an iron foundry. The nonexposed group included 40 subjects from Kasralainy outpatient clinic. Both groups were subjected to history taking, clinical examination, chest radiograph, spirometry, urinary silica, serum malondialdehyde (MDA), glutathione peroxidase (GPx), and 8-hydroxydeoxyguanosine (8-HdG).
Results:
Higher urinary silica, serum MDA and serum 8-HdG, whereas lower serum GPx and ventilatory functions were detected in the exposed group compared with the controls. All parameters correlated with urinary silica. The exposed silicotic subgroup had increased work duration, urinary silica, serum MDA, and serum 8-HdG, and decreased serum GPx and ventilatory functions compared with non-silicotic subgroup.
Conclusion:
Oxidative stress biomarkers were abnormal with impairment of ventilatory functions among silica-exposed workers.
More Related Videos
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:25Pulmonary Function Tests
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...