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Updated: Aug 9, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Access to Dialysis for Acute Kidney Injury in Low-Resource Settings
Brett Cullis1, Viviane Calice da Silva2, Mignon McCulloch3
1Department of Paediatrics and Child Health, University of Cape Town, Rondebosch, South Africa; Renal Unit, Hilton Life Hospital, Hilton, South Africa.
Abstract:
Acute kidney injury (AKI) is estimated to occur in approximately 13.3 million patients per year with an estimated mortality of 1.7 million. Approximately 85% of cases occur in low-resource settings where access to kidney replacement therapy (KRT) may be limited or nonexistent. The true extent of AKI, including access to KRT in developing countries, is largely unknown because appropriate systems are not in place to detect AKI or report it. Barriers to provision of KRT in low-resource settings revolve around systems management and funding, however, there also are region-specific issues. This review focuses on the epidemiology, obstacles, and solutions to improving access to KRT for AKI.
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