The preliminary study on cardiac structure and function in Chinese patients with primary hyperparathyroidism

Area of Science:

• Cardiology
• Endocrinology
• Internal Medicine

Background:

• Primary hyperparathyroidism (PHPT) is linked to a high prevalence of cardiovascular diseases.
• Previous studies report inconsistent changes in cardiac status among PHPT patients.

Purpose of the Study:

• To evaluate cardiac structure and function in PHPT patients using echocardiography.
• To investigate the relationship between biochemical parameters and cardiac abnormalities in PHPT.

Main Methods:

• A case-control study involving 153 PHPT patients and 51 healthy controls.
• Echocardiography was used to assess cardiac structure and function.
• Biochemical parameters were retrospectively collected from PHPT patients.

Main Results:

• PHPT patients exhibited significantly lower left ventricular ejection fraction (LVEF) and E/A ratio compared to controls.
• No significant differences in left ventricular mass index (LVMI) or relative wall thickness (RWT) were observed.
• Serum calcium, PTH, phosphorus, and urine calcium levels showed correlations with E/A, but not LVEF.

Conclusions:

• PHPT patients demonstrate diastolic cardiac dysfunction, indicated by a decreased E/A ratio.
• Potential cardiac structural abnormalities, such as concentric remodeling, may be present in some PHPT patients.
• Serum calcium, phosphorus, and PTH levels appear to influence cardiac structure and function in PHPT.