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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

106
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
106
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

68
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
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Related Experiment Video

Updated: Aug 9, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

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Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.

Georgios Marinos1, Inga K Hamerich2, Reena Debray3

  • 1Research Group Medical Systems Biology, University Hospital Schleswig-Holstein Campus Kiel, Kiel University, Kiel, Schleswig-Holstein, Germany.

Biorxiv : the Preprint Server for Biology
|February 24, 2023
PubMed
Summary

Researchers developed precision prebiotics to specifically increase beneficial microbes within the microbiome. This approach uses metabolic modeling to identify compounds that boost targeted species, offering a more precise alternative to fecal transplants for modulating gut health.

Keywords:
Caenorhabditis elegansOchrobactrum vermis MYb71Pseudomonas lurida MYb11flux balance analysisgenome-scale metabolic modelsnutritional supplementsserine

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Related Experiment Videos

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Area of Science:

  • Microbiome research
  • Metabolic modeling
  • Host-microbe interactions

Background:

  • The microbiome significantly influences host health and disease.
  • Current microbiome manipulation methods lack specificity and can cause side effects.
  • There's a need for precise approaches to modulate individual microbial species or functions.

Conclusions:

  • Precision prebiotics offer a targeted strategy for microbiome modulation.
  • Metabolic modeling is an effective tool for designing precision prebiotics.
  • This approach is a foundational step towards future microbiome-targeted therapies.