Glaucoma is probably not useful as a red flag for amyloidosis
Oscar Westin1, Jawad H Butt1, Steffen Heegaard2
1The Heart Center, University Hospital of Copenhagen, Rigshospitalet, Denmark.
Scandinavian Cardiovascular Journal : SCJ
|February 24, 2023
Summary
Glaucoma, an eye condition, is not a reliable early indicator for cardiac amyloidosis in variant transthyretin amyloidosis (ATTRv) patients. Nationwide data indicate it is unlikely to serve as a useful red flag for this condition.
Area of Science:
- Ophthalmology
- Cardiology
- Genetics
Background:
- Transthyretin amyloidosis (ATTRv) can affect the retina, with ocular complications like glaucoma occurring in approximately 25% of patients.
- Glaucoma is a significant ocular manifestation of ATTRv, potentially leading to rapid vision loss.
Purpose of the Study:
- To investigate the association between glaucoma and the subsequent diagnosis of amyloidosis.
- To determine if glaucoma serves as a useful red flag for cardiac amyloidosis.
Main Methods:
- A national-scale, retrospective cohort study comparing individuals with glaucoma to an age- and sex-matched general population cohort.
- Adjusted Cox proportional hazards models were utilized to analyze the association.
Main Results:
- The study included 365,496 subjects in a 1:1 ratio.
- No significant association was found between a glaucoma diagnosis and the future development of amyloidosis (Hazard Ratio: 1.16, p=0.44).
Conclusions:
- Ocular involvement, including glaucoma, can be an early sign of variant transthyretin amyloidosis (ATTRv).
- However, nationwide data suggest glaucoma is not a reliable red flag for identifying cardiac amyloidosis.
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