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Segmental stiff skin syndrome treated with secukinumab
Alexa Gelinas1, Julie Powell2, Chantal Lapointe3
1Faculty of Medecine, Universite de Montreal, Montreal, Canada.
Pediatric Dermatology
|February 24, 2023
Summary
Segmental stiff skin syndrome is a rare fibrosing disorder. A patient with this condition improved with anti-interleukin-17 (IL-17) biologic therapy, offering a potential new treatment avenue.
Area of Science:
- Dermatology
- Rheumatology
- Fibrotic Disorders
Background:
- Segmental stiff skin syndrome (SSSS) is a rare, progressive fibrosing disorder.
- It presents with skin indurations, joint contractures, reduced mobility, and pain.
- Current treatment options for SSSS are limited.
Observation:
- This report details a case of SSSS.
- The patient experienced significant improvement following treatment.
- The therapeutic agent used was an anti-interleukin-17 (IL-17) biologic therapy.
Findings:
- Anti-IL-17 biologic therapy demonstrated efficacy in managing SSSS symptoms.
- The patient showed positive response to this novel therapeutic approach.
- This suggests a potential role for IL-17 inhibition in SSSS treatment.
Implications:
- This finding opens new therapeutic possibilities for SSSS patients.
- Targeting IL-17 may be a viable strategy for managing this rare fibrosing condition.
- Further research is warranted to confirm the efficacy and safety of anti-IL-17 therapies in SSSS.
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