[Should antihypertensive pharmacotherapy have occupational limitations?]

Neurophysiologic effects of a course of treatment with reserpin (0.5-0.75 mg/day), dopegyt (750-1500 mg/day), clophelin (0.3-0.6 mg/day), anaprilin (80-160 mg/day), hydrochlorothiazide (25-100 mg/day) were examined in 294 patients with first- and second-stage essential hypertension (EH), using the correction test and the numbers-finding test, determination of the highest data processing rate by the Diagnoz-2 device, and the time of response to sound and light stimulation under monotonous conditions. There were no significant differences in test results between EH patients treated with the above-mentioned drugs and the placebo-treated ones. Neither single doses, nor courses taken in hospital (1 to 3 weeks) or outpatient clinic (6 to 36 months) produced any regular suppressive effect on the neurophysiologic status of EH patients.