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Development of GTP-responsive liposomes by exchanging the metal-DPA binding site in a synthetic lipid switch

Jinchao Lou1, Macy M Hudson1, Christelle F Ancajas1

  • 1Department of Chemistry, University of Tennessee, Knoxville, TN, 37996, USA. mdbest@utk.edu.

Chemical Communications (Cambridge, England)
|February 24, 2023
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Phosphoinositides and PIPs01:42

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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...