Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Post-traumatic Stress Disorder

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...

Traumatic Memory

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...

Dissociative Disorders

Dissociative Disorders

Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...

Dissociative Identity Disorder

Dissociative Identity Disorder

Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...

Introduction to Stress and Lifestyle

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Characteristic spatiotemporal features of large-scale functional network architecture in posttraumatic stress disorder.

Translational psychiatry·2026

Same author

Causal mechanisms of quadruple networks in pediatric bipolar disorder.

Psychological medicine·2024

Same author

Personality Traits and Quality of Life Among Older Adults: The Chain Mediating Effects of Perceived Social Support and Positive Coping Styles.

The Journal of genetic psychology·2024

Same author

Cell-type-specific genes associated with cortical structural abnormalities in pediatric bipolar disorder.

Psychoradiology·2024

Same author

Distinct functional patterns in child and adolescent bipolar and unipolar depression during emotional processing.

Cerebral cortex (New York, N.Y. : 1991)·2023

Same author

The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates.

Personality and mental health·2022

Search research articles

Related Experiment Video

Updated: Aug 9, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Altered dynamic functional connectivity associates with post-traumatic stress disorder.

Yingliang Dai^1,2, Zhou Zhou^1,2, Feng Chen³

¹School of Psychology, Nanjing Normal University, Nanjing, 210097, Jiangsu, China.

Brain Imaging and Behavior

|February 24, 2023

Summary

This study reveals dynamic functional connectivity (dFC) abnormalities in the Default Mode Network and cerebellum in individuals with post-traumatic stress disorder (PTSD), impacting emotional regulation and self-referential thought.

Keywords:

Dynamic functional connectivity Neural networks Post-traumatic stress disorder

More Related Videos

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

Related Experiment Videos

Last Updated: Aug 9, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

Area of Science:

Neuroscience
Psychiatry
Medical Imaging

Background:

Post-traumatic stress disorder (PTSD) is linked to neural pathophysiology and altered functional connectivity.
Previous research highlights impairments in the Default Mode Network (DMN) and cerebellum in PTSD.

Purpose of the Study:

To investigate dynamic functional connectivity (dFC) on a whole-brain level in PTSD patients.
To explore dFC characteristics in PTSD, comparing patients, healthy controls, and trauma-exposed individuals.

Main Methods:

Resting-state functional magnetic resonance imaging (rs-fMRI) data from 27 PTSD patients, 30 healthy controls, and 33 trauma-exposed individuals were analyzed.
Group spatial independent component analysis (ICA) with a sliding time window and k-means clustering identified two recurring functional connectivity (FC) states.
Focus was placed on whole-brain dFC, particularly within the DMN and cerebellum.

Main Results:

Two distinct FC states were identified: one with within-network concentration and another with strong inter-network connectivity.
PTSD patients exhibited abnormal dFC within the DMN, between the DMN and cerebellum, and between the DMN and visual network.
These dFC abnormalities correlated with PTSD symptoms like depression, anxiety, hypervigilance, and impaired cognitive/self-referential processing.

Conclusions:

Dynamic functional connectivity alterations in PTSD suggest deficits in emotional modulation and self-referential thought processing.
dFC patterns may serve as potential biomarkers for PTSD and its associated cognitive and emotional symptoms.