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Distinct functional patterns in child and adolescent bipolar and unipolar depression during emotional processing
Yun Wu1,2,3, Yuan Zhong1,2,3, Gui Zhang1,2,3
1School of Psychology, Nanjing Normal University, 122 Ninghai Road, Gulou District, Nanjing, Jiangsu 210097, China.
Cerebral Cortex (New York, N.Y. : 1991)
|December 3, 2023
Summary
Pediatric bipolar disorder (PBD) and pediatric major depressive disorder (p-MDD) show distinct brain activation patterns during emotional processing. PBD impacts emotion perception regions, while p-MDD affects emotion appraisal and regulation circuits.
Area of Science:
- Neuroscience
- Psychiatry
- Developmental Psychology
Background:
- Functional magnetic resonance imaging (fMRI) studies indicate brain dysfunction in emotional processing for adults with bipolar disorder (BD) and major depressive disorder (MDD).
- Distinct neural activation patterns may exist in pediatric populations, requiring further investigation.
Purpose of the Study:
- To investigate common and distinct brain activation patterns in pediatric bipolar disorder (PBD) and pediatric major depressive disorder (p-MDD) during emotion processing.
- To utilize meta-analytic approaches to synthesize findings from existing neuroimaging studies.
Main Methods:
- Conducted a literature search to identify relevant fMRI studies.
- Performed nine meta-analyses comparing PBD patients with healthy controls (HCs) and p-MDD patients with HCs.
- Analyzed data from 25 studies involving 252 PBD patients and 311 p-MDD patients.
Main Results:
- PBD and p-MDD exhibited distinct brain activation patterns during negative emotional processing.
- PBD patients showed activity changes in the precuneus, inferior parietal gyrus, angular gyrus, and posterior cingulate cortex.
- p-MDD patients displayed functional disruptions in the rectus, inferior frontal gyrus, orbital frontal cortex, insula, and putamen.
Conclusions:
- PBD-related brain activity changes are primarily associated with emotion perception.
- p-MDD-related dysfunction involves fronto-limbic and reward-related circuits crucial for emotion appraisal and regulation.
Keywords:
bipolar disorderfunctional magnetic resonance imagingmajor depressive depressionmeta-analysisMore Related Videos
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