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A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
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Higher Mental Functions of Brain: Learning and Memory01:26

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Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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System of Memory01:23

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Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
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Related Experiment Video

Updated: Aug 9, 2025

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
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STDP-based associative memory formation and retrieval.

Hong-Gyu Yoon1, Pilwon Kim2

  • 1Department of Mathematical Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan Metropolitan City, 44919, Republic of Korea.

Journal of Mathematical Biology
|February 24, 2023
PubMed
Summary
This summary is machine-generated.

Spike-timing-dependent plasticity (STDP) forms a "memory plane" for storing and retrieving associative memories. This neurodynamical model reveals STDP

Keywords:
92-10

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Spike-timing-dependent plasticity (STDP) is crucial for synaptic modification based on precise spike timing.
  • Previous research primarily focused on STDP's role in neural coding.
  • The macroscopic implications of STDP in brain function remain underexplored.

Purpose of the Study:

  • To investigate the macroscopic functional implications of STDP in the brain.
  • To propose a neurodynamical model utilizing STDP for associative memory storage and retrieval.
  • To elucidate the role of STDP in encoding high-dimensional data at a macroscopic level.

Main Methods:

  • Development of a novel neurodynamical model incorporating STDP.
  • Mathematical derivation of the relationship between neural input, the memory plane, and neural oscillations.
  • Analysis of memory retrieval mechanisms triggered by memory cues.

Main Results:

  • STDP facilitates the formation of a macroscopic "memory plane" in neural state space.
  • This memory plane dynamically encodes high-dimensional data.
  • An analytic relationship was established between input, memory plane, and induced neural oscillations.
  • The memory plane generates a limit cycle for memory retrieval.

Conclusions:

  • STDP plays a significant role in macroscopic brain function beyond neural coding.
  • The proposed model demonstrates STDP's capability for associative memory storage and retrieval.
  • The concept of a "memory plane" offers a new perspective on how the brain encodes and retrieves information.