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High endothelial venules in cancer: Regulation, function, and therapeutic implication

Gerlanda Vella1, Yichao Hua1, Gabriele Bergers1

  • 1Laboratory of Tumor Microenvironment and Therapeutic Resistance, Department of Oncology, VIB-Center for Cancer Biology, KU Leuven, Leuven, Belgium.

Cancer Cell
|February 24, 2023
PubMed
Summary

Inducing tumor high endothelial venules (TU-HEVs) can enhance cancer immunotherapy by increasing T cell infiltration. This review explores TU-HEV formation in tumors versus lymph nodes to improve anti-tumor immunity.

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