Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments
Kristina A Malsagova1, Arthur T Kopylov1, Alexander A Stepanov1
1Biobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.
Sports (Basel, Switzerland)
|February 24, 2023
Summary
High-intensity exercise in heat alters athlete metabolism and immune responses. Personalized monitoring of biochemical and dietary factors is crucial for optimizing training and preventing adverse reactions.
Area of Science:
- Exercise Physiology
- Sports Science
- Biochemistry
Background:
- High-intensity training (HIT) poses physiological demands.
- Extreme environmental conditions, like heat (40 °C), can exacerbate these demands.
- Understanding metabolic and immunological shifts is vital for athlete performance and health.
Purpose of the Study:
- To investigate the impact of HIT in extreme heat on athlete metabolism.
- To assess the immunological reactions of athletes post-exercise under these conditions.
- To correlate metabolic and immunological changes with training and dietary factors.
Main Methods:
- Recruited male triathletes (n=11) with high training levels.
- Conducted maximal effort exercise testing to failure and assessed maximal oxygen consumption.
- Utilized mass spectrometric metabolomic analysis on pre- and post-exercise plasma samples.
Main Results:
- Identified significant changes in 21 out of 30 metabolites and 4 out of 6 hormones post-exercise.
- Observed alterations in tricarboxylic acid cycle and amino acid intermediates (Fold Change > 1.5).
- Revealed personalized immunological reactions, including hyperactive responses to food components.
Conclusions:
- High-intensity exercise in heat significantly impacts athlete metabolism.
- Individual monitoring of biochemical markers aids in identifying training-related shortcomings.
- Personalized dietary analysis is essential for managing food intolerances and allergies in athletes.
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