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Related Experiment Video

Updated: Aug 9, 2025

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
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Vascularized Tissue Organoids.

Hannah A Strobel1, Sarah M Moss1, James B Hoying1

  • 1Advanced Solutions Life Sciences, Manchester, NH 03101, USA.

Bioengineering (Basel, Switzerland)
|February 25, 2023
PubMed
Summary
This summary is machine-generated.

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Vascularizing organoids is key for accurate disease modeling and drug screening. Integrating microvasculature enhances tissue function and cellular dynamics in these advanced biological models.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Tissue organoids are valuable for disease modeling and drug screening.
  • Mimicking native tissue requires integrating microvasculature with parenchyma and stroma.
  • Microvasculature provides physiological perfusion and influences cellular dynamics via the perivascular niche.

Purpose of the Study:

  • To review current and developing strategies for vascularizing organoids.
  • To discuss tissue-specific vascularization approaches.
  • To highlight the importance of perfusion in organoid models.

Main Methods:

  • Review of existing literature on organoid vascularization techniques.
  • Analysis of tissue-specific requirements for vascular integration.
Keywords:
endothelialextracellular matrixmicrovesselorganoidperfusionspheroidstem cellvascular networkvascularizationvessel

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  • Discussion of perfusion methods and their impact on organoid function.

    • Main Results:

    • Vascularization strategies are advancing, with diverse approaches emerging.
    • Tissue-specific vascularization is crucial for functional organoid models.
    • Perfusion significantly impacts organoid cellular dynamics and overall function.

    Conclusions:

    • Effective organoid vascularization is critical for their application in biomedical research.
    • Future directions involve refining vascularization techniques and understanding perfusion's role.
    • Organoid models with integrated vasculature offer improved platforms for disease study and drug development.