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Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

474
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
474

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Related Experiment Video

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Peptides in Dentistry: A Scoping Review.

Louis Hardan1, Jean Claude Abou Chedid2, Rim Bourgi1,3

  • 1Department of Restorative Dentistry, School of Dentistry, Saint Joseph University, Beirut 1107 2180, Lebanon.

Bioengineering (Basel, Switzerland)
|February 25, 2023
PubMed
Summary

Peptides show promise in various dental applications, including caries management and implant osseointegration. Further clinical trials are needed to confirm these beneficial effects in dentistry.

Keywords:
antimicrobialosseointegrationsurface modificationtissue engineering

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Area of Science:

  • Biomaterials Science
  • Dental Research
  • Regenerative Medicine

Background:

  • Peptide applications in dentistry are not fully understood.
  • A comprehensive review of current peptide research in dental fields is needed.

Purpose of the Study:

  • To conduct a scoping review of scientific literature on peptide types, uses, and applications in dentistry.
  • To identify current trends and knowledge gaps in dental peptide research.

Main Methods:

  • Searched major scientific databases (PubMed/MEDLINE, Scopus, Web of Science, Embase, Scielo).
  • Included 133 articles with experimental designs (in vitro, in vivo) and some clinical trials.
  • Focused on peptide applications in various dental fields.

Main Results:

  • Peptides are investigated for caries management, implant osseointegration, guided tissue regeneration, vital pulp therapy, and antimicrobial activity.
  • Applications include enamel remineralization, periodontal therapy, and modifying dental materials like adhesives and resins.
  • In vitro and in vivo studies indicate benefits in treating early caries, promoting cell adhesion, and enhancing implant stability.

Conclusions:

  • Peptides demonstrate potential benefits for dental applications, including tissue engineering and antimicrobial effects.
  • A significant lack of clinical trials necessitates further investigation.
  • Future research should focus on translating promising in vitro and in vivo findings into clinical dental practice.