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Related Experiment Video

Updated: Aug 9, 2025

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

Published on: June 14, 2011

Engineering In Situ Weldable Vascular Devices.

Daniel Cohn¹, Fany Widlan¹, Matt Zarek¹

¹Casali Center of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.

Bioengineering (Basel, Switzerland)

|February 25, 2023

Summary

This summary is machine-generated.

Minimally invasive stent graft implantation for abdominal aortic aneurysms is enhanced by an in situ welding strategy. This novel approach reduces insertion profiles, improving patient outcomes and expanding procedural applicability.

Keywords:

abdominal aortic aneurysm in situ welding polyurethane stent graft

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Last Updated: Aug 9, 2025

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

Published on: June 14, 2011

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

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Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Area of Science:

Biomedical Engineering
Materials Science
Vascular Surgery

Background:

Minimally invasive medical device implantation is limited by insertion profile size.
Reducing device profile is a key trend in medical device development.
Current abdominal aortic aneurysm treatments face challenges with device delivery.

Purpose of the Study:

To introduce and evaluate an in situ welding strategy for stent grafts.
To minimize the insertion profile of devices for abdominal aortic aneurysm repair.
To enhance the clinical performance and applicability of ultra-minimally invasive procedures.

Main Methods:

Developed an in situ welding strategy for sequential deployment and welding of stent graft components.
Utilized polyurethane elastomers for graft fabrication and in vivo weldable stent coatings.
Optimized polyurethane composition for reduced insertion profiles and improved welding.

Main Results:

Successfully deployed and in situ welded stent grafts in pigs via an 8F introducer.
Confirmed device patency over a three-month post-implantation period.
Demonstrated retained strength of the welded stent/graft connection with no de-welding.

Conclusions:

The in situ welding strategy facilitates easier and less injurious implantations.
This technique expands the reach of ultra-minimally invasive procedures to vulnerable patient populations.
The developed stent grafts show promising clinical performance and durability.