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Updated: Aug 9, 2025

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
Published on: October 4, 2017
Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders
Emanuela Senjor1,2, Janko Kos1,2, Milica Perišić Nanut1
1Department of Biotechnology, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.
Abstract:
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes-such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition to their lysosomal function, they are also secreted and may remain functional in the extracellular space. Upregulation of cathepsin expression is associated with several pathological conditions including cancer, neurodegeneration, and immune-system dysregulation. In this review, we present an overview of cysteine-cathepsin involvement and possible targeting options for mitigation of aberrant function in immune disorders such as inflammation, autoimmune diseases, and immune response in cancer.
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