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Updated: Aug 9, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Effect of Various Intermittent Fasting Protocols on Hyperglycemia-Induced Cognitive Dysfunction in Rats
Hani A Alfheeaid1, Ahmad A Alhowail2, Faiyaz Ahmed3
1Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia.
Intermittent fasting may help manage cognitive decline in type 2 diabetes. This study found fasting protocols reduced blood glucose and improved brain function in diabetic rats.
Area of Science:
- Endocrinology
- Neuroscience
- Metabolic Disorders
Background:
- Diabetes mellitus is a widespread metabolic condition linked to cognitive impairment.
- Type 2 diabetes mellitus (T2DM) is a significant cause of cognitive dysfunction.
- Understanding interventions for T2DM-related cognitive decline is crucial.
Purpose of the Study:
- To investigate the effects of intermittent fasting (IF) on cognitive function in a rodent model of T2DM.
- To assess the impact of IF on hyperglycemia and cognitive deficits in T2DM.
- To determine if IF protocols can mitigate T2DM-induced cognitive dysfunction.
Main Methods:
- Induction of T2DM in Sprague-Dawley rats using streptozotocin.
- Administration of various intermittent fasting protocols to T2DM rats.
- Assessment of cognitive function using Y-maze, novel object recognition, and elevated plus maze tests.
- Monitoring of blood glucose levels.
Main Results:
- T2DM rats exhibited significantly elevated blood glucose levels and impaired cognitive function.
- Intermittent fasting protocols led to a reduction in blood glucose levels.
- IF interventions resulted in notable improvements in cognitive function in the T2DM model.
- A strong association was observed between hyperglycemia and cognitive dysfunction.
Conclusions:
- Intermittent fasting protocols show promise in managing hyperglycemia associated with T2DM.
- IF may serve as a potential therapeutic strategy to counteract cognitive dysfunction in type 2 diabetes.
- Further research into IF for diabetic cognitive impairment is warranted.
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