Recent Progress in Plasmonic based Electrochemiluminescence Biosensors: A Review

Area of Science:

• Nanomaterials Science
• Analytical Chemistry
• Biomedical Engineering

Background:

• Electrochemiluminescence (ECL) analysis offers high sensitivity and a wide linear range for biomarker detection and clinical diagnostics.
• Advanced nanomaterials like graphene, gold, and quantum dots are utilized to enhance ECL biosensor performance.
• Plasmonic nanostructures are particularly significant in fabricating advanced ECL biosensors.

Purpose of the Study:

• To review recent advancements in plasmonic-based electrochemiluminescence (ECL) biosensors.
• To explore the mechanisms by which plasmonic effects influence ECL signals.
• To discuss the application of plasmonic materials in ECL biosensing and microscopy.

Main Methods:

• Review of literature on plasmonic nanostructures (noble metals, semiconductors) in ECL biosensor fabrication.
• Analysis of plasmon effects on ECL signals: quenching, enhancement, and polarization.
• Examination of plasmonic material influence on detection targets (small molecules, proteins, nucleic acids, cells).

Main Results:

• Plasmonic nanostructures significantly modulate ECL signals through resonant energy transfer and surface plasmon resonance.
• The distance between emitters and plasmonic materials, and coupling characteristics, regulate ECL output.
• Plasmonic materials have been successfully applied in ECL biosensors and microscopy, improving detection and image quality.

Conclusions:

• Plasmonic effects offer a powerful strategy to enhance the analytical performance of ECL biosensors.
• These materials enable sensitive detection of diverse analytes and improved ECL imaging.
• Further integration of plasmonic effects holds promise for future ECL technologies and diagnostics.