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Related Experiment Video

Updated: Aug 9, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Craniofacial Development Is Fine-Tuned by Sox2.

Nikolaos Panagiotis Mandalos^1,2, Aikaterini Dimou^1,3, Maria Angeliki Gavala^1,4

¹University Research Institute of Maternal and Child Health & Precision Medicine, School of Medicine, National and Kapoditrian University of Athens, 115 27 Athens, Greece.

|February 25, 2023

Summary

This summary is machine-generated.

Sox2 is crucial for precise neural crest stem cell development, ensuring proper head and craniofacial formation. This review details how Sox2 orchestrates cell signaling for accurate developmental processes.

Keywords:

Sox1 Sox14 Sox21 Sox3 SoxB genes SoxB1 SoxB2 development differentiation embryonic stem cells induced pluripotent stem cells neural crest stem cells neural progenitor cells neural stem cells neurogenesis regeneration

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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

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Last Updated: Aug 9, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

Area of Science:

Developmental Biology
Stem Cell Biology
Craniofacial Development

Background:

Precise regulation of neural crest stem cell (NCSC) delamination, migration, and differentiation is essential for normal craniofacial and head development.
The transcription factor Sox2 plays a significant role in shaping the ontogeny of cranial neural crest cells, influencing cell flow during head development.

Approach:

This review synthesizes current research on the role of Sox2 in cranial neural crest development.
It examines the signaling pathways orchestrated by Sox2 that control key developmental processes.

Key Points:

Sox2 acts as a master regulator in cranial neural crest development.
Sox2 influences NCSC delamination, migration, and differentiation.
Sox2 integrates various signaling pathways to ensure precise cell behavior.

Conclusions:

Sox2 is a critical orchestrator of signals governing NCSC behavior during head development.
Understanding Sox2's role provides insights into mechanisms underlying craniofacial development and potential therapeutic targets.