Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enabling 3D electrical stimulation of adipose-derived decellularized extracellular matrix and reduced graphene oxide scaffolds <i>in vitro</i> using graphene electrodes.

RSC advances·2025

Same author

Osteogenic and Antibacterial Response of Levofloxacin-Loaded Mesoporous Nanoparticles Functionalized with <i>N</i>-Acetylcysteine.

Pharmaceutics·2025

Same author

Bone regeneration in sheep model induced by strontium-containing mesoporous bioactive glasses.

Biomaterials advances·2025

Same author

Metabolomic characterization of MC3T3-E1pre-osteoblast differentiation induced by ipriflavone-loaded mesoporous nanospheres.

Biomaterials advances·2024

Same author

Biocompatible adipose extracellular matrix and reduced graphene oxide nanocomposite for tissue engineering applications.

Materials today. Bio·2024

Same author

Functionality of macrophages encapsulated in porcine decellularized adipose matrix hydrogels and interaction with Candida albicans.

Biomaterials advances·2024

Search research articles

Related Experiment Video

Updated: Aug 9, 2025

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Mesoporous Bioactive Nanoparticles for Bone Tissue Applications.

Daniel Arcos^1,2, María Teresa Portolés^2,3

¹Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.

International Journal of Molecular Sciences

|February 25, 2023

Summary

Bioactive mesoporous nanoparticles (MBNPs) show great promise for bone regeneration due to their unique porous structure and drug-carrying capabilities. These advanced nanomaterials offer enhanced cellular responses for treating bone defects and diseases.

Keywords:

bioactivity bone regeneration cellular response drug delivery in vivo studies mesoporous nanoparticles therapeutic ions

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Related Experiment Videos

Last Updated: Aug 9, 2025

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Area of Science:

Biomaterials Science
Nanotechnology
Regenerative Medicine

Background:

Bioactive mesoporous nanoparticles (MBNPs) are advanced nanomaterials with significant potential in bone regeneration therapies.
They possess a composition similar to bioactive glasses, featuring high surface area and porosity that stimulate bone tissue growth.
Their small size allows cellular penetration, enabling specific responses beyond conventional bone grafts.

Purpose of the Study:

To comprehensively review the synthesis, properties, and applications of MBNPs in bone regeneration.
To discuss the role of MBNPs as drug delivery systems and their potential in treating bone pathologies.
To explore the cellular responses and in vivo efficacy of MBNPs.

Main Methods:

Review of existing literature on MBNP synthesis and characterization.
Analysis of studies on MBNP drug delivery capabilities and therapeutic ion incorporation.
Evaluation of research on MBNP cellular interactions and in vivo performance.

Main Results:

MBNPs demonstrate tunable porosity and composition for optimized bone regeneration.
They serve as effective platforms for delivering therapeutic agents and ions to target sites.
MBNPs elicit specific cellular responses and show promise in preclinical bone defect models.

Conclusions:

MBNPs represent a significant advancement in nanomaterials for bone regeneration.
Their design flexibility and therapeutic potential offer new avenues for treating bone defects and diseases.
Further in vivo studies are crucial to fully establish the clinical utility of MBNPs.