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Updated: Aug 9, 2025

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review.

Federico Boschi¹, Manuela Malatesta²

¹Department of Computer Science, University of Verona, I-37100 Verona, Italy.

International Journal of Molecular Sciences

|February 25, 2023

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Nanotechnology offers new ways to diagnose and treat bladder cancer by overcoming the urothelial barrier. Nanoparticle imaging techniques show promise for detecting bladder cancer cells and improving patient outcomes.

Area of Science:

Biomedical Engineering
Nanomedicine
Oncology

Background:

Bladder cancer presents diagnostic and therapeutic challenges due to the impermeable urothelium.
Tumor detection and treatment are hindered by poor molecular penetration and imprecise tissue labeling.
Recurrent bladder cancer significantly impacts patient quality of life and incurs substantial socioeconomic costs.

Purpose of the Study:

To explore recent advancements in nanoparticle-based imaging for bladder cancer detection.
To provide a technical guide for developing nanoconstructs for specific bladder cancer cell targeting.
To assess the potential of nanotechnology in improving bladder cancer diagnosis and treatment.

Main Methods:

Review of experimental applications of nanoparticle-based imaging techniques.

Keywords:

bladder cancer fluorescent imaging magnetic resonance imaging nanotechnology optical imaging scanning laser fluorescent microscopy urothelium

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Last Updated: Aug 9, 2025

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

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Published on: January 12, 2017

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

Focus on fluorescence imaging and magnetic resonance imaging (MRI) modalities.

Evaluation of nanoconstructs designed to cross the urothelial barrier and target cancer cells.

Main Results:

Nanoconstructs demonstrate the ability to penetrate the urothelial barrier.
Nanoparticle imaging techniques showed positive results in preclinical in vivo bladder cancer models.
Functionalized nanoconstructs facilitated targeted delivery and visualization of bladder cancer cells.

Conclusions:

Nanotechnology holds significant promise for enhancing bladder cancer diagnosis and therapy.
Nanoparticle-based imaging offers a viable strategy to overcome the urothelial barrier.
Successful preclinical results suggest a strong potential for clinical translation in bladder cancer management.