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Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers

Ljuba Bacharova1, Marta Kollarova2, Branislav Bezak2,3,4

  • 1International Laser Center CVTI, 841 04 Bratislava, Slovakia.

International Journal of Molecular Sciences
|February 25, 2023
PubMed

Insights

Left ventricular hypertrophy (LVH) involves left ventricle enlargement, potentially causing heart failure and arrhythmias. This review covers key biomarkers for assessing LVH and guiding targeted therapies.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Molecular Medicine

Background:

  • Left ventricular hypertrophy (LVH) is a significant cardiac remodeling process.
  • LVH can lead to severe complications, including heart failure and ventricular arrhythmias.
  • Current diagnostic approaches primarily rely on imaging for anatomical assessment.

Purpose of the Study:

  • To review the main biomarkers used in evaluating left ventricular hypertrophy.
  • To highlight the role of molecular and genetic markers in understanding hypertrophic remodeling.
  • To explore the potential of biomarkers for targeted LVH therapies.

Main Methods:

  • Review of existing literature on LVH biomarkers.
  • Analysis of diagnostic imaging techniques (echocardiography, cardiac MRI).
  • Exploration of novel molecular and genetic markers.

Main Results:

  • Imaging methods are crucial for diagnosing anatomical LVH.
  • Functional assessment requires additional methods beyond imaging.
  • Molecular and genetic biomarkers offer insights into underlying pathological processes.

Conclusions:

  • Biomarkers are essential for a comprehensive evaluation of LVH.
  • Novel biomarkers hold promise for developing targeted therapeutic strategies.
  • Integrating biomarker data with imaging can improve patient management for LVH.

Keywords:
biomarkersleft ventricular hypertrophyventricular tachyarrhythmias

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