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Related Experiment Video

Updated: Jun 27, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Left ventricular electrical remodelling: a review.

Ljuba Bacharova¹, Niraj Varma², Douglas D Schocken³

¹Premedix, Bratislava, Slovakia.

Heart (British Cardiac Society)

|June 25, 2026

Summary

This summary is machine-generated.

The traditional electrocardiogram (ECG) diagnosis of left ventricular hypertrophy (LVH) is flawed. A new framework, Left Ventricular Electrical Remodeling (LVER), better captures electrical changes and patient risk.

Keywords:

Electrocardiography MYOCARDIAL FIBROSIS RISK STRATIFICATION

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Last Updated: Jun 27, 2026

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Published on: April 30, 2020

Area of Science:

Cardiology
Biophysics
Medical Imaging

Background:

The traditional Voltage Paradigm for diagnosing left ventricular hypertrophy (LVH) via ECG assumes a linear relationship between QRS amplitude and left ventricular mass.
High-resolution cardiac imaging reveals significant discrepancies, with many anatomic LVH cases showing normal QRS amplitudes and vice versa.

Purpose of the Study:

To propose a new framework, Left Ventricular Electrical Remodeling (LVER), to replace the term 'ECG-LVH'.
To incorporate non-spatial determinants affecting ECG signals, such as conduction velocity and fibrosis, into a comprehensive model.

Main Methods:

The study introduces LVER, encompassing four distinct phenotypes: high QRS amplitude, conduction delay, low QRS amplitudes, and QRS fragmentation.
This framework is endorsed by leading electrocardiology societies.

Main Results:

Each LVER phenotype represents a unique electrophysiological substrate.
These phenotypes provide prognostic information independently of left ventricular mass.

Conclusions:

LVER offers a more accurate approach to assessing cardiac electrical status than the traditional Voltage Paradigm.
Reframing the clinical task as electrical risk phenotyping improves patient risk stratification.