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Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
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Recent Advances in Methods for Circulating Tumor Cell Detection.

Monika Vidlarova1,2, Alona Rehulkova1,2, Pavel Stejskal1,2

  • 1Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, 779 00 Olomouc, Czech Republic.

International Journal of Molecular Sciences
|February 25, 2023
PubMed
Summary

Circulating tumor cells (CTCs) are key indicators of cancer spread and survival. This review covers current and emerging methods for detecting and analyzing these vital cancer biomarkers.

Keywords:
characterizationcirculating tumor cellsdetectionenrichmentmicrofluidic

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Circulating tumor cells (CTCs) shed from primary tumors and can form micrometastases.
  • CTCs are recognized as a negative prognostic factor in various cancers.
  • CTCs offer insights into tumor heterogeneity, progression, senescence, and dormancy.

Purpose of the Study:

  • To review existing and novel methods for CTC enrichment, detection, isolation, and characterization.
  • To highlight the significance of CTCs in understanding cancer biology and patient outcomes.

Main Methods:

  • Literature review of current and emerging CTC isolation and characterization techniques.
  • Analysis of methods based on specificity, utility, cost, and sensitivity.

Main Results:

  • A diverse array of methods exists for CTC analysis, each with unique advantages and limitations.
  • Ongoing development of novel techniques aims to improve CTC detection and characterization capabilities.

Conclusions:

  • Understanding CTCs is crucial for cancer prognosis and comprehending tumor biology.
  • Advancements in CTC analysis methods are vital for improving cancer diagnostics and treatment strategies.