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COVID-19-Related Neuropathic Pain: A Systematic Review and Meta-Analysis
Laura Dawn Williams1, Panagiotis Zis1,2,3
1Medical School, University of Sheffield, Sheffield S10 2RX, UK.
Introduction:
SARS-CoV-2, responsible for the coronavirus disease (COVID-19) pandemic, may impact other systems apart from the respiratory system, including the nervous system. In this systematic review, we aimed to establish the prevalence and determinants of neuropathic pain amongst COVID-19-infected individuals.
Methodology:
A literature search in the PubMed database was performed and 11 papers were eligible for inclusion in this systematic review and meta-analysis.
Results:
The pooled prevalence of COVID-19-related neuropathic pain was 6.7% (95% CI: 4.7-9.5%) for hospitalised patients during the acute phase and 34.3% (95% CI: 14.3-62%) for long COVID patients. The identified risk factors for COVID-19-related neuropathic pain development included depression, COVID-19 severity and azithromycin use.
Conclusions:
Neuropathic pain is a very common symptom in long COVID, indicating the urgency for further research in this direction.
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