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Is Hypovitaminosis D a Risk Factor for Heart Failure?
Asmaa Carla Hagău1, Amalia Pușcaș2, Rodica Togănel3
1Doctoral School of Medicine and Pharmacy, I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540136 TarguMures, Romania.
Life (Basel, Switzerland)
|February 25, 2023
Summary
Vitamin D deficiency is linked to a higher risk of heart failure. While studies show an association, more research is needed to confirm if vitamin D supplements improve outcomes.
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- Vitamin D deficiency is associated with increased cardiovascular morbidity and mortality.
- A higher risk of developing heart failure is linked to low vitamin D levels.
- Previous studies suggest a connection between vitamin D status and heart failure development.
Purpose of the Study:
- To systematically review recent studies on vitamin D deficiency and heart failure.
- To assess the relationship in both adult and pediatric populations.
- To evaluate the current evidence on vitamin D's role in heart failure.
Main Methods:
- Systematic literature search conducted on PubMed and Scopus.
- Studies published between January 2012 and October 2022 were included.
- Focused on observational studies and randomized controlled trials investigating vitamin D and heart failure.
Main Results:
- Most observational studies found a significant association between low vitamin D levels (hypovitaminosis D) and heart failure.
- Evidence from randomized controlled trials on the benefits of vitamin D supplementation is limited and controversial.
- A consistent link between vitamin D deficiency and heart failure was observed across included studies.
Conclusions:
- Vitamin D may serve as a valuable cardiovascular marker in patients with heart failure.
- Further well-designed studies are required to clarify the relationship between vitamin D and heart failure.
- The potential benefits of vitamin D supplementation for improving long-term heart failure outcomes remain uncertain.
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