Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

751
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
751
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

697
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
697

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardized Perioperative Thrombosis Prevention in Neonatal Modified Blalock-Taussig Shunt Surgery: An Algorithm-Based Single-Center Case Series.

Children (Basel, Switzerland)·2026
Same author

Early clinical outcomes and quality of life assessment after HeartMate 3 implantation: A single-centre descriptive study.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
Same author

Correction: Preoperative Indicators of Graft Rejection in Patients With Heart Transplantation: A Single-Center Retrospective Study.

Cureus·2026
Same author

Right ventricular failure after LVAD support: A challenging case of bridge to heart transplantation in end-stage dilated cardiomyopathy.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
Same author

Basal-Predominant Right-Ventricular Dysfunction in Pediatric Dilated Cardiomyopathy: An Integrated Biventricular Strain Analysis.

Biomedicines·2026
Same author

Left Atrial Deformation in Paediatric Dilated and Hypertrophic Cardiomyopathy: Insights from Two-Dimensional Speckle-Tracking Echocardiography.

Journal of clinical medicine·2025

Related Experiment Video

Updated: Mar 29, 2026

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.9K

Multichamber Strain Imaging and Biomarker Profiling for 1-Year Risk Stratification in Pediatric Dilated

Iolanda Muntean1,2, Asmaa-Carla Hagau3,4, Diana-Ramona Iurian2,3

  • 1Department of Paediatrics III, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.

Life (Basel, Switzerland)
|March 28, 2026
PubMed
Summary

This study found that multichamber strain imaging and NT-proBNP levels can help predict 1-year outcomes in children with dilated cardiomyopathy (DCM). These tools aid in identifying high-risk patients for advanced heart failure therapies.

Keywords:
pediatric biomarkerspediatric cardiomyopathypediatric heart failurespeckle-tracking echocardiography

More Related Videos

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.9K
Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
09:43

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

1.9K

Related Experiment Videos

Last Updated: Mar 29, 2026

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.9K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.9K
Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
09:43

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

1.9K

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Imaging
  • Biomarkers in Heart Disease

Background:

  • Dilated cardiomyopathy (DCM) in children is rare but serious, often progressing to heart failure (HF) and heart transplant (HTx).
  • Accurate short-term risk stratification is crucial for pediatric DCM patients, yet prognostic tools are limited.
  • Early identification of high-risk children can guide timely intervention and management.

Purpose of the Study:

  • To assess the 1-year prognostic value of multichamber speckle-tracking echocardiography (STE) and biomarkers in children with DCM.
  • To evaluate age-adjusted N-terminal pro-B-type natriuretic peptide (NT-proBNP) and vitamin D as prognostic markers.
  • To identify reliable markers for predicting major adverse events within one year.

Main Methods:

  • A prospective cohort study involving 29 children with idiopathic DCM and 27 healthy controls.
  • Standardized clinical, laboratory, and echocardiographic assessments, including multichamber STE.
  • Primary endpoint: a 12-month composite of ICD implantation, LVAD, HTx, or all-cause mortality.

Main Results:

  • 31% of DCM patients experienced major adverse events within 1 year.
  • Impaired left ventricular global longitudinal strain (LVGLS), reduced right ventricular free wall strain (RVFWSL), and lower left atrial strain rate (LASr) were associated with adverse events.
  • Elevated Z-score log NT-proBNP was significantly higher in the event group.
  • LVGLS, Zlog NT-proBNP, and LASr demonstrated excellent discrimination for 1-year events (AUCs 0.91, 0.91, and 0.87).

Conclusions:

  • Multichamber strain imaging (LVGLS, LASr) combined with age-adjusted NT-proBNP are promising exploratory markers for short-term risk stratification in pediatric DCM.
  • These markers can support earlier follow-up intensification and timely referral for advanced heart failure therapies.
  • Validation in larger, multicenter cohorts is warranted to confirm these findings.