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Acute Aortic Syndrome: From Risk Factors to Hospital Burden and Healthcare Resource Utilization
Cosmin Marian Banceu1,2, Diana Mariana Banceu3,4, Marius Mihai Harpa2,5
1Department ME 2, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
Clinics and Practice
|July 27, 2026
Summary
Acute aortic syndrome (AAS) requires rapid diagnosis to reduce mortality and healthcare costs. Optimizing care through early detection, risk stratification, and system-level pathways can shorten hospital stays and lower expenses.
Area of Science:
- Cardiovascular Medicine
- Health Systems Research
- Genetics
Background:
- Acute aortic syndrome (AAS) encompasses serious aortic conditions demanding prompt diagnosis and intervention.
- Mortality and resource utilization in AAS are significantly impacted by diagnostic timeliness, extent, malperfusion, and treatment urgency.
Purpose of the Study:
- To review contemporary evidence on factors influencing prolonged hospitalization, ICU use, and costs in AAS patients.
- To present a resource-oriented framework linking patient characteristics and clinical events to healthcare outcomes.
Main Methods:
- A narrative review of studies, registries, guidelines, and cost analyses from major databases (PubMed/MEDLINE, Scopus, Web of Science, Google Scholar).
- Literature search focused on publications from January 2000 to May 2026, emphasizing recent findings.
Main Results:
- Identified determinants of prolonged hospitalization and high resource use include hypertension, advanced age, female sex, smoking, hereditary aortopathies, hemodynamic instability, malperfusion, delayed diagnosis, and operative complexity.
- These factors correlate with increased ICU length of stay, total hospital stay, reoperations, readmissions, and need for surveillance.
Conclusions:
- AAS places a substantial burden on healthcare systems due to complex management and lifelong follow-up needs.
- Strategies like earlier diagnosis, risk stratification, genetic assessment, modifiable risk factor control, and dedicated aortic networks can improve efficiency and reduce costs.
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