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Potential Drug-Drug Interactions among Patients with Schizophrenia Spectrum Disorders: Prevalence, Association with
Cvetka Bačar Bole1, Katja Nagode2, Mitja Pišlar2
1Psychiatric Hospital Idrija, 5280 Idrija, Slovenia.
Medicina (Kaunas, Lithuania)
|February 25, 2023
Summary
Hospitalized schizophrenia patients face high risks of drug-drug interactions (pDDIs), often involving antipsychotics. Managing polypharmacy and monitoring patients are crucial for preventing adverse events.
Area of Science:
- Psychiatry
- Clinical Pharmacology
- Pharmacoepidemiology
Background:
- Polypharmacy is common in schizophrenia treatment.
- Potential drug-drug interactions (pDDIs) pose risks in this patient population.
- Understanding pDDI prevalence and associated factors is critical for patient safety.
Purpose of the Study:
- To determine the prevalence of pDDIs in hospitalized schizophrenia patients.
- To identify factors associated with pDDIs.
- To explore links between pDDIs and observed clinical symptoms/signs.
Main Methods:
- Cross-sectional observational study of 311 inpatients.
- Utilized LexiComp drug interaction program (2014 and 2021 versions).
- Multivariable regression analysis to assess associations.
Main Results:
- Prevalence of pDDIs was 88.7%.
- Common interactions involved antipsychotics and benzodiazepines, risking serious adverse effects.
- Increased number of prescribed drugs was a significant risk factor for pDDIs.
Conclusions:
- Schizophrenia patients are highly susceptible to pDDIs.
- Optimizing drug therapy and vigilant patient monitoring are essential.
- Drug interaction software aids in preventing adverse drug events.
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