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Predictive Values of Hematological Parameters for Determining Imminent Brain Death: A Retrospective Study
Eralp Çevikkalp1, Mevlüt Özgür Taşkapılıoğlu2
1Departments of Anaesthesiology and İntensive Care, Bursa City State Hospital, 16110 Bursa, Turkey.
Medicina (Kaunas, Lithuania)
|February 25, 2023
Summary
Inflammatory markers like neutrophil-to-lymphocyte ratio (NLR) can predict brain death after intracranial hemorrhage. These simple blood tests offer a reliable method for early detection and clinical course evaluation.
Area of Science:
- Neurology
- Hematology
- Critical Care Medicine
Background:
- Intracranial hemorrhage (ICH) triggers an inflammatory response involving monocytes, macrophages, and neutrophils.
- Inflammatory markers are crucial for assessing disease progression and clinical outcomes.
Purpose of the Study:
- To investigate the predictive value of specific inflammatory cell counts and ratios for the development of brain death following ICH.
- To establish easily accessible biomarkers for early brain death prediction.
Main Methods:
- Patients with Glasgow Coma Scale (GCS) score < 7 were divided into brain death (BD) and ICH groups.
- Measurements included neutrophil, lymphocyte, platelet, and monocyte counts, along with NLR, PLR, LMR, and PNR at admission.
Main Results:
- Elevated white blood cell count, neutrophil count, NLR, and PLR were significant indicators of brain death.
- Reduced lymphocyte count, LMR, and PNR also correlated with brain death.
- AUC values for NLR, PNR, PLR, and LMR ranged from 0.56 to 0.63, indicating moderate discriminatory power.
Conclusions:
- Neutrophil-to-lymphocyte ratio (NLR), platelet-to-neutrophil ratio (PNR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are reliable predictors of brain death.
- These ratios can be determined through a standard complete blood count (CBC), offering a cost-effective diagnostic tool.
