Related Experiment Video
Updated: Aug 8, 2025
04:30
Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
Published on: January 17, 2025
1.2K
Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents
Renáta Novotná1, Denisa Škařupová1, Jiří Hanyk1
1Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
Molecules (Basel, Switzerland)
|February 25, 2023
Summary
Natural compounds like hesperetin, hesperidin, rutinose, and rhamnose show anti-aging potential by reducing skin inflammation and matrix metalloproteinases. They also boost collagen production, offering a promising strategy against skin aging.
Area of Science:
- Biochemistry
- Dermatology
- Gerontology
Background:
- Aging is a complex process accelerated by factors like high blood glucose and UV exposure.
- Accumulation of damaged proteins (oxidized, glycated) drives inflammation and chronic disease progression.
- Antiglycating agents are explored for aging prevention, with natural compounds showing promise.
Purpose of the Study:
- To investigate the anti-aging effects of hesperetin, hesperidin, rutinose, and rhamnose.
- To evaluate their impact on normal human dermal fibroblasts (NHDFs) at different ages.
- To assess their potential as preventive agents against skin aging.
Main Methods:
- Compounds tested for anti-aging activity on NHDFs.
- Matrix metalloproteinases (MMPs) and inflammatory interleukins measured via ELISA.
- Enzyme activities (elastase, hyaluronidase, collagenase) assessed spectrophotometrically.
- Skin aging models used to evaluate compound effects.
Main Results:
- Rutinose and rhamnose inhibited elastase, hyaluronidase, and collagenase.
- Hesperidin and hesperetin inhibited elastase and hyaluronidase.
- All tested compounds reduced MMP-1 and MMP-2 levels in skin aging models.
- Rhamnose and rutinose increased Collagen I production.
Conclusions:
- Hesperetin, hesperidin, rutinose, and rhamnose demonstrate significant anti-aging properties.
- These compounds modulate key enzymes and proteins involved in skin aging.
- Natural compounds offer a viable strategy for preventing and managing skin aging.
More Related Videos
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
4.0K
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
7.2K
Related Concept Videos
01:15Reticular Dermis
2.7K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
2.7K
01:12Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
01:19Pigmentation
2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K
01:20Radical Autoxidation
2.2K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.2K
01:23Glycosaminoglycans
4.9K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.9K
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K