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A mechanistic updated overview on lycopene as potential anticancer agent.

Gulay Ozkan1, Deniz Günal-Köroğlu1, Ayse Karadag2

  • 1Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 25, 2023
PubMed
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Lycopene, a potent antioxidant, shows significant anticancer potential by inhibiting cancer cell growth and promoting apoptosis. Its effectiveness is influenced by factors like dosage and delivery systems.

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Area of Science:

  • Carotenoid research
  • Molecular oncology
  • Nutritional science

Background:

  • Growing interest in the link between lycopene intake and reduced cancer incidence.
  • Lycopene's role as a powerful antioxidant and its potential health benefits.

Purpose of the Study:

  • To review in vivo and in vitro research on lycopene's anticancer mechanisms.
  • To detail the experimental conditions and general characteristics of lycopene.
  • To explore lycopene's molecular and cellular effects across various tumor types.

Main Methods:

  • Comprehensive literature review of scientific articles.
  • Databases searched: PubMed/MedLine, Web of Science, Scopus, TRIP, Google Scholar.
  • Inclusion of in vitro, animal, and clinical trial data.

Main Results:

  • Lycopene exhibits anticancer potential through singlet oxygen quenching and antioxidant enzyme stimulation.
  • Mechanisms include apoptosis induction, inhibition of cell proliferation and cell cycle progression.
  • Modulation of gap junctional communication, growth factors, and signal transduction pathways observed.

Conclusions:

  • Lycopene's anticancer properties are multifaceted, involving direct cellular effects and signaling pathway modulation.
  • Factors such as dose, delivery systems, cancer type, tumor size, and treatment duration influence efficacy.
  • Further research into lycopene's therapeutic applications is warranted.