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Ganodermanontriol and Lanostane Triterpenoid Derivatives in Cancer Cell Biology: Signaling Network Modulation,

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Ganodermanontriol (GDNT), a compound from Ganoderma lucidum, shows anticancer effects by inducing apoptosis and inhibiting tumor growth. Further research may lead to its use in cancer treatment.

Keywords:
Ganoderma lucidumapoptosiscancer therapyganodermanontriolnatural productstriterpenoids

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Area of Science:

  • Pharmacology
  • Oncology
  • Natural Products

Background:

  • Ganoderma lucidum has a history of medicinal use.
  • Ganodermanontriol (GDNT) is a triterpenoid with potential anticancer properties.
  • The precise role and mechanisms of GDNT in cancer require further investigation.

Purpose of the Study:

  • To comprehensively review preclinical studies on GDNT's anticancer activity.
  • To elucidate the molecular mechanisms underlying GDNT's effects.
  • To explore the potential of GDNT and its derivatives in cancer therapy.

Main Methods:

  • Literature search and evaluation of preclinical studies (in vitro and in vivo).
  • Analysis of studies investigating GDNT's impact on various cancer types.
  • Examination of molecular pathways involved in GDNT's anticancer action.

Main Results:

  • GDNT demonstrated anticancer activity across multiple cancer types.
  • Key pathways modulated by GDNT include NF-κB/MAPK, TLR4/MyD88, Wnt/β-catenin, and androgen receptor signaling.
  • GDNT induces apoptosis, cell cycle arrest, inhibits proliferation, migration, invasion, and modulates the tumor microenvironment.

Conclusions:

  • GDNT exhibits significant preclinical anticancer potential.
  • Structural optimization of GDNT analogs can enhance bioactivity.
  • GDNT and its derivatives show promise as novel cancer therapeutics, with potential as supportive agents in oncologic care.