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Hybrid extracellular vesicles for drug delivery
Coline Ducrot1, Stanislas Loiseau2, Christophe Wong3
1Chirurgie pédiatrique orthopédique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France; Team Cell Death and Pediatric Cancer, Cancer Initiation and Tumor Cell Identity Department, INSERM1052, CNRS5286, Cancer Research Center of Lyon, F-69008, Lyon, France.
Cancer Letters
|February 25, 2023
Summary
Hybrid extracellular vesicles (EVs) combine natural EVs and synthetic vectors for advanced drug delivery. This review explores their production methods and properties, highlighting potential in oncology drug development.
Area of Science:
- Biotechnology
- Nanomedicine
- Drug Delivery Systems
Background:
- Extracellular vesicles (EVs) show promise as drug delivery vectors due to their natural origin and therapeutic potential.
- Hybrid EVs, combining EVs with synthetic components, offer enhanced properties for drug delivery applications.
Purpose of the Study:
- To review methods for producing Hybrid EVs.
- To analyze the properties of Hybrid EVs and compare them with other drug delivery vectors.
- To assess the potential of Hybrid EVs in drug development, particularly for oncology.
Main Methods:
- Review of existing literature on Hybrid EV production techniques.
- Analysis of reported properties and loading metrics of Hybrid EVs.
- Comparative assessment against other drug delivery platforms.
Main Results:
- Several methods exist for Hybrid EV production, including incubation, electrostatic interactions, PEG-mediated fusion, co-extrusion, and freeze-thawing.
- Limited studies report comparable loading metrics, necessitating critical analysis.
- Hybrid EVs present unique opportunities for drug delivery and development.
Conclusions:
- Hybrid EVs represent a novel class of drug delivery vectors with potential advantages.
- Further standardization in reporting metrics is needed for direct comparison.
- These vectors hold significant promise for advancing oncology therapeutics.
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