Related Experiment Video

Updated: Aug 8, 2025

Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
06:24

Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo

Published on: July 8, 2025

360

Comparison between clevidipine and nicardipine in cerebrovascular diseases: A systematic review and meta-analysis

Ali Seifi1, Amirhossein Azari Jafari2, Seyyedmohammadsadeq Mirmoeeni2

  • 1Department of Neurosurgery, Division of Neuro Critical Care, University of Texas Health Science Center at San Antonio School of Medicine, San Antonio, TX, USA.

Clinical Neurology and Neurosurgery
|February 26, 2023
PubMed

Insights

Clevidipine reached systolic blood pressure goals faster than nicardipine in cerebrovascular disease patients, with significantly less volume infused. Further large-scale studies are needed for definitive comparisons.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Cerebrovascular diseases (CVDs) encompass a range of conditions affecting cerebral circulation.
  • Controlling acute hypertension (HTN) is crucial in managing CVDs.
  • Antihypertensive agents like clevidipine and nicardipine are used for HTN management in CVD patients.

Approach:

  • This systematic review and meta-analysis synthesized data from observational studies.
  • Searches were conducted across PubMed, Scopus, Web of Science, and gray literature.
  • Studies compared clevidipine versus nicardipine for HTN control in adult CVD patients.

Key Points:

  • Clevidipine demonstrated a trend towards faster achievement of goal systolic blood pressure (SBP) compared to nicardipine (SMD -0.04, p=0.86).
  • Significantly lower total infused volume was observed with clevidipine (SMD -0.52, p=0.03).
  • The analysis included 5 studies with 546 patients.

Conclusions:

  • Clevidipine may offer faster SBP control with reduced volume in CVD patients.
  • No statistically significant difference in time to goal SBP was found between clevidipine and nicardipine.
  • Larger prospective studies are warranted to confirm these findings and guide clinical practice.
Abstract

Keywords:
Cerebrovascular DiseasesClevidipineMeta-analysisNicardipineSystematic review

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