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Insulin‑like growth factor axis: A potential nanotherapy target for resistant cervical cancer tumors (Review)

Miguel Morales-Rodríguez1,2, Lucero Paniagua-García3, Jayanthi Narayanan2

  • 1Directorate of The Nanotechnology Engineering Division, Polytechnic University of The Valley of Mexico, Tultitlán, State of Mexico 54910, Mexico.

Oncology Letters
|February 27, 2023
PubMed

Insights

This review explores the insulin-like growth factor (IGF) system

Area of Science:

  • Oncology
  • Nanotechnology
  • Molecular Biology

Background:

  • Cervical cancer is a major global health challenge, especially in developing nations.
  • Treatment failures in cervical cancer are linked to poor screening, advanced stages, and tumor resistance.
  • The insulin-like growth factor (IGF) system, including IGF receptor 1, is crucial in cervical cancer progression and treatment resistance.

Purpose of the Study:

  • To review the role of the IGF system in cervical cancer.
  • To describe nanotechnological applications targeting the IGF system for resistant cervical cancer treatment.

Main Methods:

  • Literature review of the IGF system's involvement in cervical cancer.
  • Analysis of three nanotechnological strategies: Trap decoys, magnetic iron oxide nanoparticles, and protein nanotubes.

Main Results:

  • The IGF system significantly influences cervical cancer development, progression, survival, and resistance.
  • Nanomaterials like Trap decoys, magnetic iron oxide nanoparticles, and protein nanotubes show potential for treating resistant cervical cancers.

Conclusions:

  • The IGF system is a critical target for overcoming cervical cancer treatment resistance.
  • Nanotechnology offers promising therapeutic avenues for managing resistant cervical cancer by modulating the IGF system.
Keywords:
cervical cancer resistanceinsulin-like growth factor axisnanotherapytheranostic

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