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In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
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Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
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Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
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"French Phage Network" Annual Conference-Seventh Meeting Report.

Olivier Schiettekatte1, Elsa Beurrier2, Luisa De Sordi3

  • 1Palais de la Découverte, Universcience, 75008 Paris, France.

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|February 28, 2023
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Summary

The French Phage Network conference highlighted recent breakthroughs in phage therapy and phage-bacteria interactions. Experts convened to discuss the latest research in phage applications and microbial ecology.

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Francebacterial immunitybacteriophagesecology and evolutionmobile genetic elementsphage therapy and biotechnologyphage–host interaction

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Biotechnology

Background:

  • The French Phage Network (Phages.fr) has experienced continuous growth over eight years.
  • The annual conference serves as a key event for the French phage research community.

Framework:

  • The 2022 conference was held at the Institut Pasteur, Paris, from October 11-13.
  • It featured four thematic sessions: phage-host interactions, microbial immunity, ecology/evolution, and therapeutic/biotechnological applications.
  • Keynote lectures opened each thematic session, setting the stage for in-depth discussions.

Implementation:

  • 164 participants from academia, hospitals, and industry attended.
  • 32 oral presentations and 33 posters showcased ongoing projects and breakthroughs.
  • Discussions occurred in the historical setting where phage therapy was pioneered by Felix d'Hérelle.

Implications:

  • The event fostered collaboration and knowledge exchange within the French phage research landscape.
  • It underscored the growing importance of bacteriophage research for both fundamental science and applied biotechnology.
  • The conference highlighted advancements in understanding phage-bacteria dynamics and their therapeutic potential.