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Recent Developments in Glioblastoma Therapy: Oncolytic Viruses and Emerging Future Strategies

Azzam Hamad1, Gaukhar M Yusubalieva2,3, Vladimir P Baklaushev2,3

  • 1Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Viruses
|February 28, 2023
PubMed

Insights

Oncolytic viruses (OVs) show promise for treating aggressive glioblastoma when standard therapies fail. Combining OVs with other treatments could significantly improve patient survival and represents a key research area.

Area of Science:

  • Neuro-oncology
  • Virology
  • Immunotherapy

Background:

  • Glioblastoma is an aggressive brain tumor with poor prognosis.
  • Current treatments like standard protocols and immunotherapy offer limited long-term survival benefits.

Purpose of the Study:

  • To review oncolytic virus (OV) therapy for glioblastomas.
  • To explore the potential of combining OVs with other therapeutic modalities.

Main Methods:

  • Review of existing literature on virotherapy for glioblastomas.
  • Identification and description of various OVs.
  • Analysis of OV combinations with other treatment options.

Main Results:

  • Oncolytic viruses (OVs) present a potential alternative to conventional glioblastoma treatments.
  • Combinations of OVs with other therapies may enhance treatment efficacy.
  • Personalized approaches integrating OVs are emerging.

Conclusions:

  • Virotherapy, particularly with oncolytic viruses, offers a promising avenue for glioblastoma treatment.
  • Combination strategies and personalized medicine are crucial for advancing glioblastoma therapy.
  • Further research into OV combinations is essential for developing effective treatment regimens.
Keywords:
CAR Tcancer immunotherapyglioblastomaimmunotherapynanoparticlesoncolytic virusespoliovirusproteomicsrecombinant strainviral vector

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