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Updated: Aug 8, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Pharmacokinetics of cefiderocol during extracorporeal membrane oxygenation: A case report

Jordi Riera1,2,3, Laura Domenech4, Sonia García4

  • 1Critical Care Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Perfusion
|February 28, 2023
PubMed

Insights

This study investigated cefiderocol pharmacokinetics in a patient on extracorporeal membrane oxygenation (ECMO). Understanding cefiderocol drug behavior during ECMO is crucial for treating multidrug-resistant infections.

Area of Science:

  • Pharmacokinetics and Infectious Diseases

Background:

  • Patients on extracorporeal membrane oxygenation (ECMO) often require broad-spectrum antibiotics due to high rates of multidrug-resistant (MDR) infections.
  • The extracorporeal circuit in ECMO can significantly alter drug pharmacokinetics (PK), potentially leading to antibiotic treatment failure.
  • Cefiderocol demonstrates potent in vitro activity against many MDR microorganisms, but its PK in ECMO patients is uncharacterized.
Keywords:
ECMOcefiderocolextracorporeal membrane oxygenationmicrobial drug resistancepharmacokinetics

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