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Updated: Aug 8, 2025

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
Published on: February 23, 2020
Precision mapping and transcranial magnetic stimulation of individual-specific functional brain networks in humans
Charles J Lynch1, Immanuel G Elbau1, Shasha Zhu1
1Department of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY, USA.
Abstract:
Spatial targeting in transcranial magnetic stimulation protocols does not typically account for the idiosyncratic functional organization of individual human brains. Here, we provide a protocol for implementing targeted functional network stimulation (TANS), which accounts for each individual's unique functional neuroanatomy and cortical folding patterns. Using an example dataset, we describe how to create a head model and estimate the best coil placement and stimulation intensity to minimize off-target effects. For complete details on the use and execution of this protocol, please refer to Lynch et al. (2022).1.

