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Post-TB bronchiectasis: from pathogenesis to rehabilitation
M A Martinez-Garcia1, W-J Guan2, D de-la-Rosa3
1Pneumology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain, CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Summary
Tuberculosis (TB) can cause bronchiectasis, a lung condition often affecting upper lobes. This review updates knowledge on post-TB bronchiectasis, highlighting the need for targeted management beyond general bronchiectasis care.
Area of Science:
- Pulmonology
- Infectious Diseases
- Radiology
Background:
- Tuberculosis (TB) destruction of lung parenchyma leads to pulmonary sequelae, including bronchiectasis.
- Post-TB bronchiectasis may differ clinically, prognostically, and therapeutically from other causes, often affecting upper lung lobes.
- TB is a leading cause of bronchiectasis globally, yet lacks specific management strategies.
Purpose of the Study:
- To provide an updated review of post-TB bronchiectasis.
- To cover its definition, epidemiology, pathophysiology, clinical presentation, diagnosis, and therapeutic aspects.
Main Methods:
- Minireview of existing literature on post-TB bronchiectasis.
- Analysis of clinical, prognostic, and therapeutic differences compared to other bronchiectasis aetiologies.
- Examination of epidemiological data and pathophysiology.
Main Results:
- Post-TB bronchiectasis is characterized by traction bronchiectasis and persistent inflammation with infection risk.
- It predominantly affects upper lung lobes.
- Current management does not specifically target TB-induced bronchiectasis.
Conclusions:
- Preventing TB and ensuring early diagnosis/treatment are crucial.
- Managing post-TB bronchiectasis requires limiting further lung insults like smoking.
- Targeted management strategies for post-TB bronchiectasis are needed to minimize sequelae.
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