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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Immunotherapy and Gastrointestinal Toxicities

Pierre-François Simand1, Nathalie Baudoux1, Thibaud Kössler1

  • 1University Hospital of Geneva, Geneva, Switzerland.

Praxis
|March 1, 2023
PubMed

Gastrointestinal toxicities secondary to immune checkpoint inhibitors are very frequent. Because in some instances this can be severe or fatal, it is essential to be able to identify immune-related adverse events rapidly. Prompt initiation of systemic immunosuppression can improve outcomes. A biopsy is often necessary to confirm the diagnosis of immune-related adverse events. Moderate or severe irAEs need an interruption of ICI. After the resolution of the toxicities, the rechallenge of immune checkpoint inhibitors must be discussed case by case.

Keywords:
ColitisHepatitisImmuncheckpoint-Inhibitoren ToxizitätenImmune checkpoint inhibitorsInhibiteurs de point de contrôle immunitaireManagementcolitecolitishepatitishépatitemanagementprise en chargetoxicitiestoxicités

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