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Organelle Communication: Joined in Sickness and in Health
Roberto Bravo-Sagua1,2,3, Camila Lopez-Crisosto1, Alfredo Criollo1,4
1Advanced Center for Chronic Diseases (ACCDiS), Faculty of Pharmaceutical and Chemical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Physiology (Bethesda, Md.)
|March 1, 2023
Summary
Cellular organelles communicate through various principles to coordinate functions. Disruptions in this communication are linked to diseases, highlighting the importance of understanding interorganelle interactions beyond the well-known endoplasmic reticulum-mitochondria contacts.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Organelles are essential membrane-bound compartments within cells that perform specialized biochemical functions.
- Interorganelle communication is critical for coordinating cellular responses and maintaining homeostasis.
- Dysregulation of organelle interactions is implicated in various human diseases.
Purpose of the Study:
- To explore the fundamental principles governing interorganelle communication.
- To highlight the significance of diverse organelle interactions in cellular function and disease.
- To broaden the scope of investigation beyond established endoplasmic reticulum-mitochondria contacts.
Main Methods:
- Review of existing literature on organelle interactions.
- Analysis of principles governing interorganelle communication (e.g., proximity, continuity, bidirectionality).
- Examination of pathological implications of altered organelle crosstalk.
Main Results:
- Interorganelle communication is governed by multiple complex principles including position, multilingualism, continuity, heterogeneity, proximity, and bidirectionality.
- Alterations in organelle communication are associated with a range of diseases.
- While endoplasmic reticulum-mitochondria interactions are well-studied, other organelle contacts are increasingly recognized for their pathophysiological relevance.
Conclusions:
- Understanding the multifaceted nature of interorganelle communication is vital for comprehending cellular function and disease mechanisms.
- Further research into diverse organelle interactions beyond ER-mitochondria is warranted to uncover new therapeutic targets.
- Interorganelle communication represents a critical area for investigating disease pathogenesis.
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