Ru(II)-Catalyzed One-Pot Synthesis of 1,2-Hydropyridines via a Three-Component Reaction
Juntao Yang1, Bingxian Liu1, Junbiao Chang1
1NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, Pingyuan Laboratory, Xinxiang, Henan 453007, China.
Abstract:
A ruthenium(II)-catalyzed one-pot synthesis of highly substituted 1,2-dihydropyridines (DHPs) via a three-component reaction system has been realized. The reaction is conducted using a simple Ru(II) catalyst without the addition of specific ligands. The catalytic system exhibits good functionality tolerance with a wide range of starting materials. The DHPs obtained can be easily converted into tetrahydropyridines and azabicyclo[4.2.0]octa-4,7-dienes by subsequent reduction or [2 + 2] cycloaddition reaction.
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