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Lipoprotein-Associated Phospholipase A2 Correlates with Reduced Left Ventricle Ejection Fraction in Hemodialysis

Chen Jun-Feng1, Jin Xiao-Ping2, Zhang Juan2

  • 1Department of Nephrology, Shidong Hospital, University of Shanghai for Science and Technology, Shanghai, China.

Laboratory Medicine
|March 1, 2023
PubMed

Insights

Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are linked to reduced left ventricular ejection fraction (LVEF) in hemodialysis patients. Higher Lp-PLA2 may indicate impaired heart function in this population.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Reduced left ventricular ejection fraction (LVEF) is prevalent in hemodialysis (HD) patients.
  • Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a key factor in cardiovascular events.

Purpose of the Study:

  • To investigate the association between Lp-PLA2 and LVEF in HD patients.
  • To determine if Lp-PLA2 can serve as a marker for reduced LVEF in this cohort.

Main Methods:

  • Fifty-seven HD patients with coronary heart disease were analyzed.
  • Blood samples were collected pre- and post-dialysis.
  • Patients were grouped by preserved versus reduced LVEF for comparison.

Main Results:

  • Higher levels of Lp-PLA2 and C-reactive protein (CRP) were found in patients with reduced LVEF (P ≤ .001).
  • Both Lp-PLA2 and CRP showed a negative correlation with LVEF.
  • Lp-PLA2 was independently associated with LVEF in multivariate analysis.

Conclusions:

  • Lp-PLA2 levels correlate with LVEF in HD patients.
  • Lp-PLA2 may aid in evaluating and managing chronic heart failure with reduced LVEF in HD patients for risk stratification.
Abstract

Keywords:
C-reactive proteinN-terminal proBNPheart failurehemodialysisleft ventricular ejection fractionlipoprotein-associated phospholipase A2

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